Uveitis

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Overview, Causes, & Risk Factors

Uveitis is an inflammation inside the eye, affecting the uvea. The uvea provides most of the blood supply to the retina. Causes of uveitis can include autoimmune disorders, infection, or exposure to toxins. However in many cases, the cause remains unknown.

The most common form of uveitis is anterior uveitis, which involves inflammation in the front part of the eye, which is usually isolated to the iris. This condition is often called iritis. The inflammation may be associated with autoimmune diseases such as rheumatoid arthritis or ankylosing spondylitis, but most cases occur in healthy people and do not indicate an underlying disease. The disorder may affect only one eye and is most common in young and middle-aged people. A history of an autoimmune disease is a risk factor.

Pars planitis is inflammation of the pars plana, a narrow area between the iris and the choroid. Pars planitis usually occurs in young men and is not associated with any other disease. It is usually mild.

Posterior uveitis affects the back portion of the uveal tract and involves primarily the choroid. This is called choroiditis. If the adjacent retina is also involved it is called chorioretinitis. Posterior uveitis may follow a systemic infection or occur in association with an autoimmune disease.

The inflammation causes spotty areas of scarring on the choroid and retina that correspond to areas with vision loss. The degree of vision loss depends on the amount and location of scarring. If the central part of the retina, called the macula is involved, central vision becomes impaired.

Uveitis, affecting one or both eyes, can be associated with any of the following:

• Toxoplasmosis
• Histoplasmosis
• Tuberculosis
• Sarcoidosis
• Syphilis
• AIDS
• CMV retinitis or other cytomegalovirus infection
• Sympathetic ophthalmia following trauma
• Ulcerative colitis
• Rheumatoid arthritis
• Kawasaki disease
• Herpes zoster infection
• Ankylosing spondylitis
• Behcet's syndrome
• Psoriasis
• Reiter's syndrome