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Multiple Endocrine Neoplasia (MEN) II
Alternate Names : Sipple's Syndrome
Definition
Multiple Endocrine Neoplasia II (MEN II) is a hereditary disorder in which patients develop a type of thyroid cancer accompanied by recurring cancer of the adrenal glands.
One type of this disease (MEN IIa) is also associated with overgrowth (hyperplasia) of the parathyroid gland.
Pictures & Images
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Overview, Causes, & Risk Factors
The cause of MEN II is genetic -- a mutation in a gene called RET. Multiple tumors may appear in the same person, but not necessarily at the same time. The adrenal tumor is a pheochromocytoma and the thyroid tumor is a medullary carcinoma of the thyroid.
The disorder may occur at any age, and affects men and women equally. The main risk factor is a family history of MEN II.
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• Definition
• Overview, Causes, & Risk Factors
• Symptoms & Signs
• Prevention
• Diagnosis & Tests
• Treatment
• Prognosis
• Complications
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Diseases & Conditions
• Cancer
• Hyperparathyroidism
• Medullary Carcinoma of Thyroid
• Pheochromocytoma
• Tumor
Tests & Exams
• Abdominal CT Scan
• Abdominal MRI
• Adrenal Biopsy
• ALP
• Calcitonin
• Catecholamines - Urine
• ECG
• Hyperplasia
• MIBG (Iodine-131-Meta-Iodobenzylguanidine) Scintiscan
• Parathyroid Biopsy
• PTH
• Serum Calcium
• Serum Phosphorus
• Thyroid Excisional Biopsy
• Thyroid Scan
• Thyroid Ultrasound
Other Topics
• Abdominal Pain
• Appetite - Decreased
• Back Pain - Low
• Chest Pain
• Cough
• Coughing Up Blood
• Depression
• Diarrhea
• Endocrine
• Fatigue
• Fever
• Headache
• Heartbeat Sensations
• High Blood Pressure
• Metastasis
• Nausea and Vomiting
• Nodules
• Pulse - Bounding
• Sweating - Excessive
• Thirst - Excessive
• Urination - Excessive Volume
• Weakness
• Weight Loss - Unintentional
Review Date : 5/2/2003
Reviewed By : Ezra E. W. Cohen, M.D., Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL. Review provided by VeriMed Healthcare Network.
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